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Article

Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres.

Cell - 17 Sept 2004

Hayashi Takeshi, Fujita Yohta, Iwasaki Osamu, Adachi Yoh, Takahashi Kohta, Yanagida Mitsuhiro

Abstract excerpt

Centromeres contain specialized chromatin that includes the centromere-specific histone H3 variant, spCENP-A/Cnp1. Here we report identification of five fission yeast centromere proteins, Mis14-18. Mis14 is recruited to kinetochores independently of CENP-A, and, conversely, CENP-A does not require Mis14 to associate with centromeres. In contrast, Mis15, Mis16 (strong similarity with human RbAp48 and RbAp46),...

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Identifiers

PMID: 15369671
DOI: 10.1016/j.cell.2004.09.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres.PMID 15369671Read ↗

Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly.Semantic proximity Read ↗

Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1.Semantic proximity Read ↗

Molecular basis for the centromere association of the CENP-A specific chaperone HJURP, a key regulator of centromere maintenanceSemantic proximity Read ↗

Subunit interactions and arrangements in the fission yeast Mis16-Mis18-Mis19 complex.Semantic proximity Read ↗

A NASP (N1/N2)-related protein, Sim3, binds CENP-A and is required for its deposition at fission yeast centromeres.Semantic proximity Read ↗

Fission yeast Scm3: A CENP-A receptor required for integrity of subkinetochore chromatin.Semantic proximity Read ↗

M18BP1 valency and a distributed interaction footprint determine epigenetic centromere specification in humansSemantic proximity Read ↗

Schizosaccharomyces pombe centromere protein Mis19 links Mis16 and Mis18 to recruit CENP-A through interacting with NMD factors and the SWI/SNF complex.Semantic proximity Read ↗

Requirement of Mis6 centromere connector for localizing a CENP-A-like protein in fission yeast.Semantic proximity Read ↗

Sim4: a novel fission yeast kinetochore protein required for centromeric silencing and chromosome segregation.Semantic proximity Read ↗

Identification of Novel α-N-Methylation of CENP-B That Regulates Its Binding to the Centromeric DNASemantic proximity Read ↗

The FACT complex interacts with the E3 ubiquitin ligase Psh1 to prevent ectopic localization of CENP-A.Semantic proximity Read ↗

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