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Article

Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly.

Open biology - 30 Apr 2014

Subramanian Lakxmi, Toda Nicholas R T, Rappsilber Juri, Allshire Robin C

Abstract excerpt

CENP-A chromatin forms the foundation for kinetochore assembly. Replication-independent incorporation of CENP-A at centromeres depends on its chaperone HJURP(Scm3), and Mis18 in vertebrates and fission yeast. The recruitment of Mis18 and HJURP(Scm3) to centromeres is cell cycle regulated. Vertebrate Mis18 associates with Mis18BP1(KNL2), which is critical for the recruitment of Mis18 and HJURP(Scm3). We identify...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24789708
DOI: 10.1098/rsob.140043
PMCID: PMC4043117

Genes

HJURP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly.PMID 24789708Read ↗

Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres.Semantic proximity Read ↗

Molecular basis for the centromere association of the CENP-A specific chaperone HJURP, a key regulator of centromere maintenanceSemantic proximity Read ↗

A Dual Inhibitory Mechanism Sufficient to Maintain Cell-Cycle-Restricted CENP-A Assembly.Semantic proximity Read ↗

CENP-C functions as a scaffold for effectors with essential kinetochore functions in mitosis and meiosis.Semantic proximity Read ↗

Subunit interactions and arrangements in the fission yeast Mis16-Mis18-Mis19 complex.Semantic proximity Read ↗

Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1.Semantic proximity Read ↗

Schizosaccharomyces pombe centromere protein Mis19 links Mis16 and Mis18 to recruit CENP-A through interacting with NMD factors and the SWI/SNF complex.Semantic proximity Read ↗

Chl4p and iml3p are two new members of the budding yeast outer kinetochore.Semantic proximity Read ↗

A NASP (N1/N2)-related protein, Sim3, binds CENP-A and is required for its deposition at fission yeast centromeres.Semantic proximity Read ↗

Distinct pools of CENP-A and CENP-C support unique phases of centromere assembly in spermatogenesisSemantic proximity Read ↗

Ctf3p, the Mis6 budding yeast homolog, interacts with Mcm22p and Mcm16p at the yeast outer kinetochore.Semantic proximity Read ↗

The CENP-A N-tail confers epigenetic stability to centromeres via the CENP-T branch of the CCAN in fission yeast.Semantic proximity Read ↗

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