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Article

A Dual Inhibitory Mechanism Sufficient to Maintain Cell-Cycle-Restricted CENP-A Assembly.

Molecular cell - 19 Jan 2017

Stankovic Ana, Guo Lucie Y, Mata João F, Bodor Dani L, Cao Xing-Jun, Bailey Aaron O, Shabanowitz Jeffrey, Hunt Donald F, Garcia Benjamin A, Black Ben E, Jansen Lars E T

Abstract excerpt

Chromatin featuring the H3 variant CENP-A at the centromere is critical for its mitotic function and epigenetic maintenance. Assembly of centromeric chromatin is restricted to G1 phase through inhibitory action of Cdk1/2 kinases in other phases of the cell cycle. Here, we identify the two key targets sufficient to maintain cell-cycle control of CENP-A assembly. We uncovered a single phosphorylation site in the...

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Identifiers

PMID: 28017591
DOI: 10.1016/j.molcel.2016.11.021
PMCID: PMC5250512

Genes

HJURP

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Research trail→

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A Dual Inhibitory Mechanism Sufficient to Maintain Cell-Cycle-Restricted CENP-A Assembly.PMID 28017591Read ↗

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