Article

Molecular basis for the centromere association of the CENP-A specific chaperone HJURP, a key regulator of centromere maintenance

2021-01-01

Abstract excerpt

Centromeres are epigenetically defined by the histone H3 variant, CENPA, which is crucial for faithful chromosome segregation and genome stability. CENP-A is distributed equally to sister chromatids during DNA replication in the S phase necessitating CENP-A replenishment in each round of the cell cycle. CENP-A deposition is initiated by the CENP-C-mediated targeting of the Mis18 complex (Mis18a, Mis18b, Mis18BP1)...

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Literature Corpus work: 119a969a-8e33-55f8-ba1f-2b5c3bb39d3b
DOI: 10.7488/era/1170

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