Article

AlphaFold-Guided Structural PPI Profiling Distinguishes Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma

2025-07-29

Abstract excerpt

Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) remain challenging to differentiate using conventional imaging and single-gene diagnostics. Here, we introduce a novel approach leveraging AlphaFold3-guided structural profiling of protein-protein interactions (PPIs), integrating evolutionary distances (ClustalW dnd) and structural affinity metrics (CS) derived from predicted PPI complexes. W...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5ff97d5e-0088-534c-a53c-438d524c74e0
DOI: 10.20944/preprints202507.2288.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

AlphaFold-Guided Structural PPI Profiling Distinguishes Hepatocellular Carcinoma and Intrahepatic CholangiocarcinomaDOI 10.20944/preprints202507.2288.v1Read

Computed cancer interactome explains the effects of somatic mutations in cancers.Semantic proximity Read

Computed cancer interactome explains the effects of somatic mutations in cancersSemantic proximity Read

Comprehensive Atomic-Scale 3D Viral-Host Protein Interactomes Enable Dissection of Key Mechanisms and Evolutionary Processes Underlying Viral PathogenesisSemantic proximity Read

Structurally-informed human interactome reveals proteome-wide perturbations by disease mutationsSemantic proximity Read

Non-coding small RNAs buffer protein interactions to prevent oncogenic aggregation: structural dampening of aberrant PPIs by RNA.Semantic proximity Read

A multiscale functional map of somatic mutations in cancer integrating protein structure and network topologySemantic proximity Read

Interpretation of cancer mutations using a multiscale map of protein systems.Semantic proximity Read

Towards a structurally resolved human protein interaction networkSemantic proximity Read

Functional and Topological Properties in Hepatocellular Carcinoma TranscriptomeSemantic proximity Read

Cell type-centric interaction networks define spatial architecture of intrahepatic cholangiocarcinomaSemantic proximity Read

Towards a structurally resolved human protein interaction network.Semantic proximity Read

A structurally informed human protein-protein interactome reveals proteome-wide perturbations caused by disease mutations.Semantic proximity Read