Article
Interpretation of cancer mutations using a multiscale map of protein systems.
Science (New York, N.Y.) - 1 Oct 2021
Zheng Fan, Kelly Marcus R, Ramms Dana J, Heintschel Marissa L, Tao Kai, Tutuncuoglu Beril, Lee John J, Ono Keiichiro, Foussard Helene, Chen Michael, Herrington Kari A, Silva Erica, Liu Sophie N, Chen Jing, Churas Christopher, Wilson Nicholas, Kratz Anton, Pillich Rudolf T, Patel Devin N, Park Jisoo, Kuenzi Brent, Yu Michael K, Licon Katherine, Pratt Dexter, Kreisberg Jason F, Kim Minkyu, Swaney Danielle L, Nan Xiaolin, Fraley Stephanie I, Gutkind J Silvio, Krogan Nevan J, Ideker Trey
Abstract excerpt
A major goal of cancer research is to understand how mutations distributed across diverse genes affect common cellular systems, including multiprotein complexes and assemblies. Two challenges—how to comprehensively map such systems and how to identify which are under mutational selection—have hindered this understanding. Accordingly, we created a comprehensive map of cancer protein systems integrating both new...
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