Article

Cell type-centric interaction networks define spatial architecture of intrahepatic cholangiocarcinoma

2026-06-06

Abstract excerpt

Tumor spatial organization critically shapes disease progression and therapeutic response, yet remains poorly defined. Intrahepatic cholangiocarcinoma (iCCA), a rare and aggressive liver malignancy with extensive stromal and immune remodeling, provides a compelling model to study tumor architecture. We generated a single-cell spatial atlas of 1 million cells from 131 iCCA patients using 53-plex spatial proteomics....

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Literature Corpus work: 26e2f880-7cee-53cd-a838-c84e3786d85d
DOI: 10.64898/2026.06.02.729644

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