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Article

Non-coding small RNAs buffer protein interactions to prevent oncogenic aggregation: structural dampening of aberrant PPIs by RNA.

RNA biology - 1 Dec 2026

Chinami Masanobu

Abstract excerpt

Non-coding RNAs (ncRNAs) modulate protein-protein interactions (PPIs) by shaping the structural context in which binding occurs, rather than acting as direct inhibitors or enhancers. Using an integrative framework combining catRAPID RNA-protein interaction prediction and AlphaFold3-based structural modelling, we analysed RNA-dependent modulation of interaction states across physiological and oncogenic protein...

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Identifiers

PMID: 41605259
DOI: 10.1080/15476286.2026.2623239
PMCID: PMC12867418

Genes

IDH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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