Article

Examining dynamics of three-dimensional genome organization with multi-task matrix factorization

2023-08-27

Abstract excerpt

Three-dimensional (3D) genome organization, which determines how the DNA is packaged inside the nucleus, has emerged as a key component of the gene regulation machinery. High-throughput chromosome conformation datasets, such as Hi-C, have become available across multiple conditions and timepoints, offering a unique opportunity to examine changes in 3D genome organization and link them to phenotypic changes in norm...

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Literature Corpus work: f9911715-a8a8-5686-87ba-b27215a9ff7f
DOI: 10.1101/2023.08.25.554883

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