Article

Long Noncoding RNAs Preserve Pancreatic Cancer Identity and Resist Cell Fate Conversion

2025-06-28

Abstract excerpt

<h4>Summary</h4> The Yamanaka factors (OCT4, SOX2, KLF4, and MYC; OSKM) can rejuvenate aging phenotypes in somatic cell types by resetting the epigenetic landscape. Curiously, most solid tumor cells remain largely resistant to reprogramming despite their well-documented plasticity, and the underlying mechanisms are unclear. Here, we combined genomic profiling and in vivo assays to investigate OSKM-mediated repro...

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Literature Corpus work: 5facb659-16e0-5e69-a5f9-0f03ea0f397d
DOI: 10.1101/2025.06.25.661419

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