Article

A Genetically Engineered Human Organoid Model Reveals Distinct Genetic and Epigenetic Barriers of Lineage Plasticity in Early PDAC Transformation

2026-03-11

Abstract excerpt

The lack of accurate, human-based models recapitulating early-stage pancreatic ductal adenocarcinoma (PDAC) has hindered therapeutic development. Using pluripotent stem cell-derived pancreatic progenitor organoids, we established a human PDAC model that faithfully reproduces the genetic, epigenetic, and transcriptomic trajectory of tumor initiation and progression in vitro , validated against clinical datasets an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 29069ef2-1024-5bda-8320-d0b666d289cb
DOI: 10.64898/2026.03.09.710586

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Genetically Engineered Human Organoid Model Reveals Distinct Genetic and Epigenetic Barriers of Lineage Plasticity in Early PDAC TransformationDOI 10.64898/2026.03.09.710586Read

Reconstitution of human PDAC using primary cells reveals oncogenic transcriptomic features at tumor onsetSemantic proximity Read

Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells.Semantic proximity Read

Pancreatic Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem CellsSemantic proximity Read

Extra-lineage tissue programs define the transcription states of human pancreatic cancerSemantic proximity Read

Long Noncoding RNAs Preserve Pancreatic Cancer Identity and Resist Cell Fate ConversionSemantic proximity Read

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids.Semantic proximity Read

Molecular Pathogenesis of Pancreatic Cancer: Advances and ChallengesSemantic proximity Read

Regulatory elements of pancreas development license the initiation of pancreatic ductal adenocarcinomaSemantic proximity Read

Ecoevolutionary biology of pancreatic ductal adenocarcinoma.Semantic proximity Read

Identification and Implications for Tumor Heterogeneity of a DNA Methylation-Based Signature Classifying Pancreatic Ductal Adenocarcinoma Based on their Cellular OriginSemantic proximity Read

Marker-based CRISPR screening reveals a MED12-p63 interaction that activates basal identity in pancreatic ductal adenocarcinomaSemantic proximity Read

Pancreatic CancerSemantic proximity Read