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Article

Re-engineering the Pancreas Tumor Microenvironment: A "Regenerative Program" Hacked

1 Apr 2017

Abstract excerpt

The "hallmarks" of pancreatic ductal adenocarcinoma (PDAC) include proliferative, invasive, and metastatic tumor cells and an associated dense desmoplasia comprised of fibroblasts, pancreatic stellate cells, extracellular matrix, and immune cells. The oncogenically activated pancreatic epithelium and its associated stroma are obligatorily interdependent, with the resulting inflammatory and immunosuppressive...

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Share to Epigenetics and DNA Methylation
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PMID: 28373363
DOI: 10.1158/1078-0432.ccr-16-3275

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