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Epigenetic reprogramming of primary pancreatic cancer cells counteracts their in vivo tumourigenicity

15 Jul 2019

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) arises through accumulation of multiple genetic alterations. However, cancer cells also acquire and depend on cancer-specific epigenetic changes. To conclusively demonstrate the crucial relevance of the epigenetic programme for the tumourigenicity of the cancer cells, we used cellular reprogramming technology to reverse these epigenetic changes. We reprogrammed human PDAC...

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PMID: 31308488
DOI: 10.1038/s41388-019-0871-x

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