Article

eIF4G2-dependent translation restrains pancreatic cancer progression

2026-03-17

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic ductal adenocarcinoma (PDA) is among the most lethal cancers, driven by cellular plasticity that fuels therapeutic resistance and early dissemination. The contribution of translational control to this plasticity remains poorly understood. Through an in vivo CRISPR/Cas9 screen, we identify the non-canonical initiation factor eIF4G2 (DAP5/NAT1) as a translational checkpoint restraining...

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Literature Corpus work: 92beb5d0-38e6-5d8c-90da-9fc660e078cc
DOI: 10.64898/2026.03.14.711799

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