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Article

Epigenetic reprogramming in pancreatic premalignancy and clinical implications

16 Feb 2023

Abstract excerpt

Pancreatic cancer (PC) is the most lethal human cancer, with less than 10% 5-year survival. Pancreatic premalignancy is a genetic and epigenomic disease and is linked to PC initiation. Pancreatic premalignant lesions include pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), and mucinous cystic neoplasm (MCN), with pancreatic acinar-to-ductal metaplasia (ADM) as the...

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PMID: 36874143
DOI: 10.3389/fonc.2023.1024151

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