Loss of PBRM1 accelerates pancreatic cancer progression by inducing acquisition of mesenchymal phenotype and inflammatory cancer-associated fibroblasts reprogramming.

doi:10.1016/j.canlet.2026.218797

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Article

Loss of PBRM1 accelerates pancreatic cancer progression by inducing acquisition of mesenchymal phenotype and inflammatory cancer-associated fibroblasts reprogramming.

Cancer letters - 28 Oct 2026

Li Jin, Que Risheng, Zhang Jian, Ma Ke, Guo Shouliang, Wen Liang, Zhao Jianhui, Chen Wen, Wang Xun, Qin Hao, Qian Danfeng, Huang Jinyan, Xie Yali, Wei Tao, Liang Tingbo

Abstract excerpt

BACKGROUND: PBRM1 is an important subunit of the SWI/SNF complex, which broadly regulates gene transcription by chromatin remodeling. Genomic alterations of PBRM1 have been found in patients with pancreatic ductal adenocarcinoma (PDAC), but its molecular functions remain unclear. METHODS: Clinical relevance of PBRM1 was analyzed by using human PDAC samples and public genomic datasets. Mice with concomitant...

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Topics

Animals
Pancreatic Neoplasms
Humans
Transcription Factors
Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mice

DNA-Binding Proteins

Cancer-Associated Fibroblasts

Disease Progression

Epithelial-Mesenchymal Transition

Phenotype

Gene Expression Regulation, Neoplastic

Nuclear Proteins

Cellular Reprogramming

Tumor Microenvironment

Cell Line, Tumor

Source

Open in PubMed

Identifiers

PMID: 42632513
DOI: 10.1016/j.canlet.2026.218797

Genes

PBRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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