Article

Regulatory elements of pancreas development license the initiation of pancreatic ductal adenocarcinoma

2025-06-08

Abstract excerpt

Cellular plasticity and transitional cellular states are crucial for tissue regeneration across multiple organs. In the pancreas, oncogenic Kras hijacks this program, acting on tissue-specific enhancers to prevent the resolution of acinar-to-ductal metaplasia (ADM) and lock regeneration into a pro-inflammatory state that progresses to cancer. Enhancer transcription, an early event during cellular state transitions...

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Literature Corpus work: c67dc54d-4b7c-56fe-873e-ea7d9a1e7733
DOI: 10.1101/2025.06.06.658264

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