Article

Loss of p53 tumor suppression function drives invasion and genomic instability in models of murine pancreatic cancer

2022-01-01

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic ductal adenocarcinoma (PDA) is a deadly disease with few treatment options. There is an urgent need to better understand the molecular mechanisms that drive disease progression, with the ultimate aim of identifying early detection markers and clinically actionable targets. To investigate the transcriptional and morphological changes associated with pancreatic cancer progression, we an...

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Literature Corpus work: ec2c1cbb-012f-5d48-a71f-1413a04cfee2
DOI: 10.1101/2021.12.31.472823

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