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Article

Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone.

Immunity - 24 Jun 2011

Kerfoot Steven M, Yaari Gur, Patel Jaymin R, Johnson Kody L, Gonzalez David G, Kleinstein Steven H, Haberman Ann M

Abstract excerpt

We identify the interfollicular (IF) zone as the site where germinal center B cell and T follicular helper (Tfh) cell differentiation initiates. For the first 2 days postimmunization, antigen-specific T and B cells remained confined within the IF zone, formed long-lived interactions, and upregulated the transcriptional repressor Bcl6. T cells also acquired the Tfh cell markers CXCR5, PD-1, and GL7. Responding B...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to T-Lymphocytes, Helper-Inducer

Source

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Identifiers

PMID: 21636295
DOI: 10.1016/j.immuni.2011.03.024
PMCID: PMC3280079

Genes

ICOS
CXCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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