Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

T‐follicular helper cell differentiation and the co‐option of this pathway by non‐helper cells

13 Apr 2012

Abstract excerpt

Human and mouse studies performed over the last decade have established that follicular helper T (Tfh) cells are a CD4(+) helper subset specialized in the provision of help to B cells. Tfh differentiation is driven by expression of the transcriptional repressor B-cell lymphoma-6 (Bcl-6), which turns on a program that guides T cells close to B-cell areas where Tfh cells first provide help to B cells. Sustained...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22500838
DOI: 10.1111/j.1600-065x.2012.01121.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

T‐follicular helper cell differentiation and the co‐option of this pathway by non‐helper cellsPMID 22500838Read ↗

Molecular Control of Follicular Helper T cell Development and DifferentiationSemantic proximity Read ↗

Mechanism of Follicular Helper T Cell Differentiation Regulated by Transcription FactorsSemantic proximity Read ↗

Functional differentiation and regulation of follicular T helper cells in inflammation and autoimmunity.Semantic proximity Read ↗

The elusive identity of T follicular helper cells.Semantic proximity Read ↗

Transcriptional and epigenetic regulation of follicular T-helper cells and their role in autoimmunitySemantic proximity Read ↗

Bcl6-Mediated Transcriptional Regulation of Follicular Helper T cells (TFH)Semantic proximity Read ↗

Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone.Semantic proximity Read ↗

Signals that drive T follicular helper cell formation.Semantic proximity Read ↗

T follicular regulatory cells in mice and men.Semantic proximity Read ↗

BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanismsSemantic proximity Read ↗

Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses.Semantic proximity Read ↗

Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.