Article

B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes

2025-11-01

Abstract excerpt

<h4>Summary</h4> Immune responses to pathogens and effective vaccines elicit germinal center (GC) responses wherein B cells undergo affinity maturation and develop into plasma cells (PCs) and memory B cells (MBCs). The GC reaction is initially seeded by a limited group of founder B cells, and subsequently further diversified by continual entry of naïve B cells that compete with GC founder cells for antigen and T...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 04ba82cb-64b5-5083-9b0a-e3eb9e73ce99
DOI: 10.1101/2025.10.30.685663

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopesDOI 10.1101/2025.10.30.685663Read

A Germinal Center–Independent Innate-Like Memory B Cell Compartment of B1 OriginSemantic proximity Read

Continuous germinal center invasion contributes to the diversity of the immune responseSemantic proximity Read

Single cell clonal analysis identifies an AID-dependent pathway of plasma cell differentiationSemantic proximity Read

Germinal center-dependent and -independent memory B cells produced throughout the immune response.Semantic proximity Read

High cRel-expressing germinal center B cells favor precursor plasma cell generationSemantic proximity Read

Single-cell analysis reveals dynamics of human B cell differentiation and identifies novel B and antibody-secreting cell intermediatesSemantic proximity Read

Complex subsets but redundant clonality after B cells egress from spontaneous germinal centersSemantic proximity Read

A dynamic activation–memory cycle organizes the human IgG⁺ memory B cell compartmentSemantic proximity Read

Single-cell analysis of germinal-center B cells informs on lymphoma cell of origin and outcomeSemantic proximity Read

Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways.Semantic proximity Read

Memory B cells: effectors of long-lived immune responses.Semantic proximity Read

Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memorySemantic proximity Read