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CD4+CD8+ T follicular helper cells regulate humoral immunity in chronic inflammatory lesions

25 Aug 2022

Abstract excerpt

T follicular helper (Tfh) cells drive humoral immunity by facilitating B cell responses at the initial and recall phases. Recent studies have indicated the possible involvement of Tfh cells in the process of chronic inflammation. However, the functional role of Tfh cells in persistent immune settings remains unclear. Here, we report that CD4+CD8+ (double-positive, DP; CD3+CD4+CD8+CXCR5hiPD-1hi) Tfh cells, a...

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PMID: 36091071
DOI: 10.3389/fimmu.2022.941385

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