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Article

The forkhead transcription factor FOXP1 represses human plasma cell differentiation

19 Aug 2015

Abstract excerpt

Expression of the forkhead transcription factor FOXP1 is essential for early B-cell development, whereas downregulation of FOXP1 at the germinal center (GC) stage is required for GC B-cell function. Aberrantly high FOXP1 expression is frequently observed in diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue lymphoma, being associated with poor prognosis. Here, by gene expression analysis upon...

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PMID: 26289642
DOI: 10.1182/blood-2015-02-626176

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