Article

The expansion in lymphoid organs of IL-4 <sup>+</sup> BATF+ T follicular helper cells is linked to IgG4 class switching <i>in vivo</i>

2018-03-19

Abstract excerpt

<h4>ABSTRACT</h4> Distinct T FH subsets that influence specific class-switching events are assumed to exist, but the accumulation of isotype-specific T FH subsets in secondary and tertiary lymphoid organs has not been hitherto demonstrated. IL-4 expressing T FH cells are surprisingly sparse in human secondary lymphoid organs. In sharp contrast, in IgG4-related disease (IgG4-RD), a disorder characterized by pol...

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Literature Corpus work: 90eb7318-f213-5d06-8a31-8644ff6ce8e9
DOI: 10.1101/284737

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