Article

Softer substrates mechanical primes durable and metabolically fit CD8+ T cells for anti-cancer activity

2026-04-24

Abstract excerpt

Adoptive T cell therapy for solid tumors is limited by poor persistence of CD8 + T cells, a dysfunction that is often programmed during ex vivo expansion. Here, we show that, when biochemical inputs are held constant,substrate mechanics alone can direct durable anti-tumor function in primary human CD8 + T cells. Using polyacrylamide (PA) hydrogels of defined stiffness (soft ∼1 kPa; stiff ∼55 kPa) in both flat an...

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Literature Corpus work: 9f9a5931-a061-56cc-99d3-7cadf83a4f7b
DOI: 10.64898/2026.04.22.720068

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