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Article

Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells.

Journal for immunotherapy of cancer - 1 May 2021

Bai Zhiliang, Lundh Stefan, Kim Dongjoo, Woodhouse Steven, Barrett David M, Myers Regina M, Grupp Stephan A, Maus Marcela V, June Carl H, Camara Pablo G, Melenhorst J Joseph, Fan Rong

Abstract excerpt

BACKGROUND: Autologous T cells engineered to express a chimeric antigen receptor (CAR) specific for CD19 molecule have transformed the therapeutic landscape in patients with highly refractory leukemia and lymphoma, and the use of donor-generated allogeneic CAR T is paving the way for further breakthroughs in the treatment of cancer. However, it remains unknown how the intrinsic heterogeneities of these engineered...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34006631
DOI: 10.1136/jitc-2020-002328
PMCID: PMC8137188

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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