Article

CAR Signaling Informs Mechanisms to Enhance Metabolism and Function in γδ T Cells

2026-02-02

Abstract excerpt

<title>Abstract</title> <p>γδ T cell-based immunotherapies have gained relevance as an alternative to the conventional αβ T cell products with pre-clinical data demonstrating tumor burden reduction and mitigation of tumor-induced damage. Given that most CAR constructs were optimized for αβ T cells, we hypothesized that distinct T cell types may require tailored CAR architectures to achieve optimal function. To te...

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Literature Corpus work: b6dc879d-ac59-5aca-93d0-047e5f3b8aa0
DOI: 10.21203/rs.3.rs-8704178/v1

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