Article

Transcript errors generate a continuous stream of amyloid and prion-like proteins in human cells

2023-05-11

Abstract excerpt

<h4>ABSTRACT</h4> Aging is characterized by the accumulation of amyloid and prion-like proteins. However, the molecular mechanisms by which these proteins arise remain unclear. Here, we demonstrate that transcript errors generate amyloid and prion-like proteins in a wide variety of human cell types, including stem cells, brain organoids, and fully differentiated neurons. Intriguingly, some of these proteins are i...

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Literature Corpus work: 5f2ced2b-3240-510c-8e1a-678ab1a8064b
DOI: 10.1101/2023.05.11.540433

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