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Article

The DNA Replication Stress Hypothesis of Alzheimer’s Disease

1 Jan 2011

Abstract excerpt

A well-recognized theory of Alzheimer's disease (AD) pathogenesis suggests ectopic cell cycle events to mediate neurodegeneration. Vulnerable neurons of the AD brain exhibit biomarkers of cell cycle progression and DNA replication suggesting a reentry into the cell cycle. Chromosome reduplication without proper cell cycle completion and mitotic division probably causes neuronal cell dysfunction and death....

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PMID: 22262948
DOI: 10.1100/2011/625690

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