Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations, protein homeostasis, and epigenetic control of genome integrity.

DNA repair - 1 Nov 2018

Xie Jinglin Lucy, Jarosz Daniel F

Abstract excerpt

From bacteria to humans, ancient stress responses enable organisms to contend with damage to both the genome and the proteome. These pathways have long been viewed as fundamentally separate responses. Yet recent discoveries from multiple fields have revealed surprising links between the two. Many DNA-damaging agents also target proteins, and mutagenesis induced by DNA damage produces variant proteins that are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteria
Share to DNA Damage
Share to DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Eukaryota

Share to Genome

Share to Neurodegenerative Diseases

Share to Proteostasis

Source

Open in PubMed Open full text

Identifiers

PMID: 30181040
DOI: 10.1016/j.dnarep.2018.08.004
PMCID: PMC6340753

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations, protein homeostasis, and epigenetic control of genome integrity.PMID 30181040Read ↗

DNA damage and regulation of protein homeostasisSemantic proximity Read ↗

Phenotypic and genetic consequences of protein damage.Semantic proximity Read ↗

Emerging Cancer Therapeutic Targets in Protein Homeostasis.Semantic proximity Read ↗

Mutation induced by DNA damage: a many protein affair.Semantic proximity Read ↗

Proteome Stability as a Key Factor of Genome IntegritySemantic proximity Read ↗

Genome instability and loss of protein homeostasis: converging paths to neurodegeneration?Semantic proximity Read ↗

Integrating the DNA damage and protein stress responses during cancer development and treatment.Semantic proximity Read ↗

Aging genomes: a necessary evil in the logic of life.Semantic proximity Read ↗

Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer StrategiesSemantic proximity Read ↗

Protein damage, radiation sensitivity and aging.Semantic proximity Read ↗

Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human CancerSemantic proximity Read ↗

Aggregation prone regions and gatekeeping residues in protein sequences.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.