Article
Genome-wide surveillance of transcription errors in response to genotoxic stress.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jan 2021
Fritsch C, Gout J-F, Haroon S, Towheed A, Chung C, LaGosh J, McGann E, Zhang X, Song Y, Simpson S, Danthi P S, Benayoun B A, Wallace D, Thomas K, Lynch M, Vermulst M
Abstract excerpt
Mutagenic compounds are a potent source of human disease. By inducing genetic instability, they can accelerate the evolution of human cancers or lead to the development of genetically inherited diseases. Here, we show that in addition to genetic mutations, mutagens are also a powerful source of transcription errors. These errors arise in dividing and nondividing cells alike, affect every class of transcripts...
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