Article
Mutation and catastrophe in the aging genome.
Experimental gerontology - 1 Aug 2017
Milholland Brandon, Suh Yousin, Vijg Jan
Abstract excerpt
In the 1960s, Leslie Orgel proposed what is now known as the error catastrophe theory of aging, arguing that errors in protein translation that reduce the fidelity of the protein-translating enzymes would lead to a feedback loop of increasingly inaccurate protein synthesis, terminating in the death of the organism. This mechanism of aging would be consistent with the exponential increase of mortality observed in...
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