Article
Transcript errors generate amyloid-like proteins in huwman cells.
Nature communications - 7 Oct 2024
Chung Claire S, Kou Yi, Shemtov Sarah J, Verheijen Bert M, Flores Ilse, Love Kayla, Del Dosso Ashley, Thorwald Max A, Liu Yuchen, Hicks Daniel, Sun Yingwo, Toney Renaldo G, Carrillo Lucy, Nguyen Megan M, Biao Huang, Jin Yuxin, Jauregui Ashley Michelle, Quiroz Juan Diaz, Head Elizabeth, Moore Darcie L, Simpson Stephen, Thomas Kelley W, Coba Marcelo P, Li Zhongwei, Benayoun Bérénice A, Rosenthal Joshua J C, Kennedy Scott R, Quadrato Giorgia, Gout Jean-Francois, Chen Lin, Vermulst Marc
Abstract excerpt
Aging is characterized by the accumulation of proteins that display amyloid-like behavior. However, the molecular mechanisms by which these proteins arise remain unclear. Here, we demonstrate that amyloid-like proteins are produced in a variety of human cell types, including stem cells, brain organoids and fully differentiated neurons by mistakes that occur in messenger RNA molecules. Some of these mistakes...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.