Article

New Protein Variants Resulting from RNA Editing May Lead to Proteotoxic Stress

2023-12-20

Abstract excerpt

<title>Abstract</title> <p>Maintaining protein homeostasis is critical for cellular function, as disruptions can result in accumulation of misfolded proteins associated with various diseases. RNA editing, particularly deamination by base-editing enzymes like ADAR, can modify the transcriptome, potentially influencing amino acid sequences and protein diversity. We hypothesize that irregular RNA editing, leading to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 338a37b8-1c29-5bb8-ad42-dc45629ab4fc
DOI: 10.21203/rs.3.rs-3744163/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

New Protein Variants Resulting from RNA Editing May Lead to Proteotoxic StressDOI 10.21203/rs.3.rs-3744163/v1Read

Mistranslating tRNA variants impact the proteome and phosphoproteome of <i>Saccharomyces cerevisiae</i>Semantic proximity Read

The Role of RNA Editing in Cancer Development and Metabolic DisordersSemantic proximity Read

Proteome diversification by adenosine to inosine RNA-editingSemantic proximity Read

Mutations, protein homeostasis, and epigenetic control of genome integrity.Semantic proximity Read

Leveraging genetics to understand ADAR1-mediated RNA editing in health and diseaseSemantic proximity Read

The implications of APOBEC3-mediated C-to-U RNA editing for human disease.Semantic proximity Read

tRNA-modifying enzyme mutations induce codon-specific mistranslation and protein aggregation in yeast.Semantic proximity Read

The RNA editing enzymes ADARs: mechanism of action and human diseaseSemantic proximity Read

A-to-I RNA editing and human disease.Semantic proximity Read

The co-chaperone DNAJA2 buffers proteasomal degradation of cytosolic proteins with missense mutationsSemantic proximity Read

Mistranslating tRNA variants impact the proteome and phosphoproteome of Saccharomyces cerevisiae.Semantic proximity Read

Liver cancer-specific mutations in functional domains of ADAR2 lead to the elevation of coding and non-coding RNA editing in multiple tumor-related genes.Semantic proximity Read