Article
Transcription errors induce proteotoxic stress and shorten cellular lifespan.
Nature communications - 25 Aug 2015
Vermulst Marc, Denney Ashley S, Lang Michael J, Hung Chao-Wei, Moore Stephanie, Moseley M Arthur, Mosely Arthur M, Thompson J Will, Thompson William J, Madden Victoria, Gauer Jacob, Wolfe Katie J, Summers Daniel W, Schleit Jennifer, Sutphin George L, Haroon Suraiya, Holczbauer Agnes, Caine Joanne, Jorgenson James, Cyr Douglas, Kaeberlein Matt, Strathern Jeffrey N, Duncan Mara C, Erie Dorothy A
Abstract excerpt
Transcription errors occur in all living cells; however, it is unknown how these errors affect cellular health. To answer this question, we monitor yeast cells that are genetically engineered to display error-prone transcription. We discover that these cells suffer from a profound loss in proteostasis, which sensitizes them to the expression of genes that are associated with protein-folding diseases in humans;...
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