Back to search

Article

Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes

2024-06-07

Abstract excerpt

Alzheimer’s disease (AD) patients often exhibit cerebral amyloid angiopathy (CAA), i.e beta-amyloid (Aβ) accumulation within cerebral blood vessels causing cerebrovascular dysfunction. Pericytes wrap around vascular capillaries, thus regulating cerebral blood flow, angiogenesis, and vessel stability. Vascular dysfunction can promote the development and progression of neurodegenerative diseases, yet the specific co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5ef8da33-9d03-5e54-8551-55271f989903
DOI
10.1101/2024.06.07.597867
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changesDOI 10.1101/2024.06.07.597867
Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes.Semantic proximity
APPswe mutation causes functional deficits in endothelial cells generated by transient ETV2 overexpression in human iPSCs.Semantic proximity
APPswe mutation causes functional deficits in endothelial cells generated by transient ETV2 overexpression in human iPSCsSemantic proximity
APOE4 promotes cerebrovascular fibrosis and amyloid deposition via a pericyte-to-myofibroblast transitionSemantic proximity
Alzheimer’s Disease Patient Brain Extracts Induce Multiple Pathologies in Vascularized Neuroimmune Organoids for Disease Modeling and Drug DiscoverySemantic proximity
Vascular models of Alzheimer's disease: An overview of recent in vitro models of the blood-brain barrierSemantic proximity
Amyloid beta peptides (Aβ) from Alzheimer’s disease neuronal secretome induce endothelial activation in a human cerebral microvessel modelSemantic proximity
Generation of an Alzheimer’s Disease Model Derived from Induced Pluripotent Stem Cells with an APP Gene MutationSemantic proximity
Dysplasia of cortical capillaries as the origin of Alzheimer’s disease: experimental evidence from APP/PS1Semantic proximity
Angiopoietin signalling is a central axis of amyloid-driven vascular dysfunction in Alzheimer’s diseaseSemantic proximity
Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons.Semantic proximity
C/EBPβ/AEP Signaling Activated by ApoE4 and 27-Hydroxycholesterol in Macrophages Mediates Cerebral Amyloid Angiopathies in Alzheimer’s DiseaseSemantic proximity
Select a neighboring publication to make it the new centre.