Article

Dysplasia of cortical capillaries as the origin of Alzheimer’s disease: experimental evidence from APP/PS1

2024-10-23

Abstract excerpt

<title>Abstract</title> <p>To investigate the time course changes of key pathological features of Alzheimer’s disease (AD) and relationship between vascular damage, neuro-inflammation and Aβ in AD model. VEGFR2 expression, vascular number and Aβ levels in cortex and cerebrospinal fluid, cortical and serum inflammatory factor levels, and autonomic activity/memory were analyzed in APP/PS1 mice from 1 to 12-month-ol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a00c8b59-b576-5853-8fd9-f39f06c3ce81
DOI: 10.21203/rs.3.rs-5219476/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dysplasia of cortical capillaries as the origin of Alzheimer’s disease: experimental evidence from APP/PS1DOI 10.21203/rs.3.rs-5219476/v1Read

Angiopoietin signalling is a central axis of amyloid-driven vascular dysfunction in Alzheimer’s diseaseSemantic proximity Read

Vascular oxidative stress causes neutrophil arrest in brain capillaries, leading to decreased cerebral blood flow and contributing to memory impairment in a mouse model of Alzheimer’s diseaseSemantic proximity Read

The Alzheimer risk factor CD2AP causes dysfunction of the brain vascular networkSemantic proximity Read

Single-cell multi-region dissection of brain vasculature in Alzheimer’s DiseaseSemantic proximity Read

Novel Pathological Mechanisms Revealed by Spatial Transcriptomic Analysis of Hippocampus in Aged Control, Primary Age-Related Tauopathy, and Alzheimer’s DiseaseSemantic proximity Read

Multi‑omics profiling reveals shared blood-brain barrier stress signatures and disease-specific vascular remodelingin capillary cerebral amyloid angiopathy and GRN-associated frontotemporal dementiaSemantic proximity Read

Shared and disease-specific human brain vascular signatures in Alzheimer’s disease, frontotemporal dementia, and Huntington’s diseaseSemantic proximity Read

Endothelial Progenitor Cells and Vascular Alterations in Alzheimer’s DiseaseSemantic proximity Read

Characterization of transcriptomic changes in the neurovascular unit of Alzheimiers transgenic mouse models using digital spatial profilingSemantic proximity Read

Vascular models of Alzheimer's disease: An overview of recent in vitro models of the blood-brain barrierSemantic proximity Read

A human brain vascular atlas reveals diverse cell mediators of Alzheimer’s disease riskSemantic proximity Read

Cerebral cortical arteriolar angiopathy, vascular beta-amyloid, smooth muscle actin, Braak stage, and APOE genotype.Semantic proximity Read