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Vascular models of Alzheimer's disease: An overview of recent in vitro models of the blood-brain barrier

13 Mar 2025

Abstract excerpt

Alzheimer's disease (AD) remains an overwhelming epidemiologic and economic burden on our healthcare systems, affecting an estimate of 11 % of individuals aged 65 years and older. Increasing evidence of the role of the blood-brain barrier (BBB) in AD pathology lends support to the vascular hypothesis of AD, which posits that damage to cerebral vasculature and impairments to cerebral blood flow are major...

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PMID: 40089165
DOI: 10.1016/j.nbd.2025.106864

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