Article

Amyloid beta peptides (Aβ) from Alzheimer’s disease neuronal secretome induce endothelial activation in a human cerebral microvessel model

2022-07-29

Abstract excerpt

In Alzheimer’s disease (AD), secretion and deposition of amyloid beta peptides (Aβ) have been associated with blood-brain barrier dysfunction. However, the role of Aβ in endothelial cell (EC) dysfunction remains elusive. Here we investigated AD mediated EC activation by studying the effect of Aβ secreted from human induced pluripotent stem cell-derived cortical neurons (hiPSC- CN) harboring a familial AD mutation...

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Literature Corpus work: c5f333fe-3a8e-561a-aa60-f3c5342a8021
DOI: 10.1101/2022.07.27.501634

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