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Article

APPswe mutation causes functional deficits in endothelial cells generated by transient ETV2 overexpression in human iPSCs.

Fluids and barriers of the CNS - 21 Nov 2025

Wu Ying-Chieh, Lehtonen Šárka, Kauppinen Riitta, Dhungana Hiramani, Koistinaho Jari, Rõlova Taisia

Abstract excerpt

BACKGROUND: Brain endothelial cells (ECs) lining blood vessels are essential for the normal function of the brain. They form the first layer of the blood-brain barrier (BBB) and regulate nutrient exchange, immune responses, and angiogenesis. Numerous studies have reported the disruption of the BBB in neurodegenerative diseases, including Alzheimer’s disease (AD). However, the impact of cell-intrinsic amyloid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41272813
DOI: 10.1186/s12987-025-00728-8
PMCID: PMC12639930

Genes

ETV2
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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