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Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes.

Fluids and barriers of the CNS - 27 Sept 2024

Wu Ying-Chieh, Lehtonen Šárka, Trontti Kalevi, Kauppinen Riitta, Kettunen Pinja, Leinonen Ville, Laakso Markku, Kuusisto Johanna, Hiltunen Mikko, Hovatta Iiris, Freude Kristine, Dhungana Hiramani, Koistinaho Jari, Rolova Taisia

Abstract excerpt

BACKGROUND: Patients with Alzheimer's disease (AD) frequently present with cerebral amyloid angiopathy (CAA), characterized by the accumulation of beta-amyloid (Aβ) within the cerebral blood vessels, leading to cerebrovascular dysfunction. Pericytes, which wrap around vascular capillaries, are crucial for regulating cerebral blood flow, angiogenesis, and vessel stability. Despite the known impact of vascular...

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Identifiers

PMID: 39334385
DOI: 10.1186/s12987-024-00576-y
PMCID: PMC11438249

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