Article

Angiopoietin signalling is a central axis of amyloid-driven vascular dysfunction in Alzheimer’s disease

2025-08-29

Abstract excerpt

<h4>ABSTRACT</h4> The neurovascular unit is critical for brain health, and its dysfunction has been linked to Alzheimer’s disease (AD). However, a cell-type-resolved understanding of how diverse vascular cells become dysfunctional and contribute to disease has been missing. Here, we applied Vessel Isolation and Nuclei Extraction for Sequencing (VINE-seq) to build a comprehensive transcriptomic atlas from 101 indi...

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Literature Corpus work: bfa90377-7413-590b-b730-91f72f169338
DOI: 10.1101/2025.08.25.672093

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