Article

Alzheimer’s Disease Patient Brain Extracts Induce Multiple Pathologies in Vascularized Neuroimmune Organoids for Disease Modeling and Drug Discovery

2024-10-28

Abstract excerpt

Alzheimer’s Disease (AD) is the most common cause of dementia afflicting 55 million individuals worldwide, with limited treatment available. Current AD models mainly focus on familial AD (fAD), which is due to genetic mutations. However, models for studying sporadic AD (sAD), which represents over 95% of AD cases without specific genetic mutations, are severely limited. Moreover, the fundamental species difference...

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Literature Corpus work: 3cfdbd92-7514-51c8-8973-66fd7f88c622
DOI: 10.1101/2024.10.28.620680

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