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Article

<i>Sarbecovirus</i> ORF6 Proteins Hamper the Induction of Interferon Signaling by Blocking mRNA Nuclear Export

2020-10-07

Abstract excerpt

The presence of an <i>ORF6</i> gene distinguishes <i>Sarbecoviruses</i> such as SARS-CoV and SARS-CoV-2 from other <i>Betacoronaviruses</i>. Here, we show that ORF6 inhibits the induction of type I IFN upon viral infection, as well as IFN types I and III signaling. Intriguingly, the anti-IFN activity of ORF6 proteins of SARS-CoV-2 lineages is more potent than that of SARS-CoV lineages. Mutational analyses identifi...

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Identifiers and source

Literature Corpus work
5ed85552-1061-5bee-ad84-1a08437273f3
DOI
10.2139/ssrn.3690468
Open publication

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