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Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis

21 Sept 2023

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes several proteins that inhibit host interferon responses. Among these, ORF6 antagonizes interferon signaling by disrupting nucleocytoplasmic trafficking through interactions with the nuclear pore complex components Nup98-Rae1. However, the roles and contributions of ORF6 during physiological infection remain unexplored. We assessed the role of...

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PMID: 37738983
DOI: 10.1016/j.chom.2023.08.003

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