Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evasion of Type I Interferon by SARS-CoV-2

19 Sept 2020

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication and host immune response determine coronavirus disease 2019 (COVID-19), but studies evaluating viral evasion of immune response are lacking. Here, we use unbiased screening to identify SARS-CoV-2 proteins that antagonize type I interferon (IFN-I) response. We found three proteins that antagonize IFN-I production via distinct mechanisms:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19 Clinical Research Studies
Share to interferon and immune responses
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32979938
DOI: 10.1016/j.celrep.2020.108234

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evasion of Type I Interferon by SARS-CoV-2PMID 32979938Read ↗

Manipulation of innate immune signaling pathways by SARS-CoV-2 non-structural proteinsSemantic proximity Read ↗

Activation and evasion of type I interferon responses by SARS-CoV-2.Semantic proximity Read ↗

Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilitiesSemantic proximity Read ↗

Roles and functions of SARS-CoV-2 proteins in host immune evasionSemantic proximity Read ↗

Interferon antagonists encoded by SARS-CoV-2 at a glanceSemantic proximity Read ↗

Multiple layers of innate immune response antagonism of SARS-CoV-2Semantic proximity Read ↗

Antagonism of Type I Interferon by Severe Acute Respiratory Syndrome Coronavirus 2.Semantic proximity Read ↗

SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation.Semantic proximity Read ↗

SARS-CoV-2 Nsp15 Suppresses Type I Interferon Production by Inhibiting IRF3 Phosphorylation And Nuclear TranslocationSemantic proximity Read ↗

Redundant and distinct mechanisms suppress innate immune activation during SARS-CoV-2 infection.Semantic proximity Read ↗

Mechanisms of impairment of interferon production by SARS-CoV-2Semantic proximity Read ↗

SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.