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Article

SARS-CoV-2 infection triggers widespread host mRNA decay leading to an mRNA export block

27 Jul 2021

Abstract excerpt

The transcriptional induction of interferon (IFN) genes is a key feature of the mammalian antiviral response that limits viral replication and dissemination. A hallmark of severe COVID-19 disease caused by SARS-CoV-2 is the low presence of IFN proteins in patient serum despite elevated levels of IFN-encoding mRNAs, indicative of post-transcriptional inhibition of IFN protein production. Here, we performed...

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PMID: 34315815
DOI: 10.1261/rna.078923.121

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