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Article

Activation and evasion of type I interferon responses by SARS-CoV-2.

Nature communications - 30 Jul 2020

Lei Xiaobo, Dong Xiaojing, Ma Ruiyi, Wang Wenjing, Xiao Xia, Tian Zhongqin, Wang Conghui, Wang Ying, Li Li, Ren Lili, Guo Fei, Zhao Zhendong, Zhou Zhuo, Xiang Zichun, Wang Jianwei

Abstract excerpt

The pandemic of COVID-19 has posed an unprecedented threat to global public health. However, the interplay between the viral pathogen of COVID-19, SARS-CoV-2, and host innate immunity is poorly understood. Here we show that SARS-CoV-2 induces overt but delayed type-I interferon (IFN) responses. By screening 23 viral proteins, we find that SARS-CoV-2 NSP1, NSP3, NSP12, NSP13, NSP14, ORF3, ORF6 and M protein...

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Identifiers

PMID: 32733001
DOI: 10.1038/s41467-020-17665-9
PMCID: PMC7392898

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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