Article

Rapid Decay of Host Basal mRNAs During SARS-CoV-2 Infection Perturbs Host Antiviral mRNA Biogenesis and Export

2021-05-27

Abstract excerpt

A key feature of the mammalian antiviral response is the transcriptional induction of interferon (IFN) genes, which encode for secreted proteins that prime the antiviral response to limit viral replication and dissemination. A hallmark of severe COVID-19 disease caused by SARS-CoV-2 is the low presence of IFNs in patient serum despite elevated levels of <i>IFN</i>-encoding mRNAs, indicative of post-transcriptional...

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Literature Corpus work: 22522bf0-0463-551f-a604-e90d6a8e5c4c
DOI: 10.2139/ssrn.3854710

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