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Article

Sarbecovirus ORF6 proteins hamper induction of interferon signaling

1 Mar 2021

Abstract excerpt

The presence of an ORF6 gene distinguishes sarbecoviruses such as severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 from other betacoronaviruses. Here we show that ORF6 inhibits induction of innate immune signaling, including upregulation of type I interferon (IFN) upon viral infection as well as type I and III IFN signaling. Intriguingly, ORF6 proteins from SARS-CoV-2 lineages are more...

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PMID: 33765414
DOI: 10.1016/j.celrep.2021.108916

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